Auvelity cost: what a month costs, with and without insurance

The price

What Auvelity costs without insurance

Auvelity is a brand-only medicine, so the cash price stays high. The best public measure of it is what pharmacies themselves pay.

CMS's National Average Drug Acquisition Cost (NADAC) comes from a monthly survey of the invoice prices that independent and chain retail pharmacies pay, updated every week. It is the pharmacy's cost before any markup or dispensing fee. On November 11, 2026, it was $19.89283 for one AUVELITY 45 mg/105 mg tablet.

Sources: CMS NADAC 2026 (rate effective October 21, 2026; 60 tablets is the per-tablet rate times 60), Amazon Pharmacy (which also offers 6% off with Prime if eligible), CMS Medicare Part D Spending by Drug (gross drug cost per fill in 2024, before manufacturer rebates) and the AUVELITY savings program, all read November 11, 2026. No price on this page is Labyrinth's or Advanced Depression Care's.

Month and year

What a month and a year of Auvelity cost

The number of tablets in a month sets the bill, and the label sets the number of tablets.

For major depressive disorder, the label starts with one tablet in the morning, then on day 4 goes to the maximum of one tablet twice a day, at least 8 hours apart. That is 60 tablets a month, and AUVELITY comes in bottles of 30 and of 60. The label lowers the maximum to one tablet a day for people with moderate kidney impairment, for known CYP2D6 poor metabolizers, and for people taking a strong CYP2D6 inhibitor. Your prescriber decides which applies; this page does not.

Arithmetic on the November 11, 2026 NADAC rate and the AUVELITY label. NADAC is the pharmacy's cost, so a pharmacy's cash price is usually higher. The label says to swallow tablets whole and not to crush, divide or chew them, so splitting is not a way to save.

Commercial insurance

The $10 savings card: who can use it

Axsome, the maker, says eligible patients can pay as little as $10 for up to a 90-day prescription. The card has firm limits.

• You must have commercial (private) health insurance and a valid prescription for an FDA-approved use.
• It is not valid with Medicare, Medicaid, TRICARE or other federal or state programs.
• Cash-paying patients are not eligible for the co-pay assistance.
• If your insurance does not cover AUVELITY, Axsome says you may get up to 2 fills (120 tablets) for as little as $10 a fill. To keep paying that, your insurance must approve coverage, so ask your prescriber about a coverage request early.
• Monthly, annual or per-claim maximums may apply. The program is not insurance.

Sources: AUVELITY OnMySide savings page and savings card terms, read November 11, 2026.

Medicare

Auvelity with Medicare Part D

Medicare drug plans do pay for Auvelity, and use has grown fast. Your own plan's drug list decides the tier, any prior authorization and your share.

• In 2024, Medicare drug plans paid for 73,075 Auvelity fills for 16,448 people, with total gross spending of $77,071,789.99. In 2023 it was 9,268 people.
• The average gross cost was $1,054.69 a fill and $18.58 a tablet in 2024. That is the drug's cost to the plan and its members together, before manufacturer rebates, not one member's copay.
• For 2026, the standard Part D deductible is $615 and the out-of-pocket threshold is $2,100. For 2027 they rise to $700 and $2,400.
• The maker's $10 card cannot be used with a Medicare drug plan.

Sources: CMS Medicare Part D Spending by Drug (2024 data) and the CMS CY 2027 Rate Announcement, read November 11, 2026.

Generic

Is there a generic Auvelity?

Not in CMS's drug-price file. On November 11, 2026, NADAC listed only brand AUVELITY products: the 45 mg/105 mg tablet in bottles of 30 and 60, and a titration pack.

Dextromethorphan and bupropion are each sold on their own, but AUVELITY is a single extended-release tablet with its own label. In the label's second study, people with major depressive disorder took AUVELITY or bupropion alone for 6 weeks, and the label says the results showed that dextromethorphan contributes to AUVELITY's effect. Switching to any other medicine to save money is a decision to make with your prescriber, not on your own.

Beyond the price

When cost is not the real question

A medicine that costs $1,000 or more a month and is not helping deserves a conversation, not just a cheaper pharmacy.

• The label carries a boxed warning: antidepressants increased the risk of suicidal thoughts and behaviors in children and young adults in short-term studies, and everyone taking one should be watched for worsening and new suicidal thoughts.
• The label says not to take AUVELITY with a seizure disorder, a current or past eating disorder (bulimia or anorexia nervosa), during abrupt stopping of alcohol, benzodiazepines, barbiturates or antiepileptic drugs, or with an MAOI or within 14 days of stopping one.
• If two or more antidepressants have not helped, ask whether you meet the criteria for treatment-resistant depression. Read what to do when antidepressants fail and our treatment-resistant depression guide.
• Other treatments have their own coverage rules. See what TMS costs and SPRAVATO cost and insurance.